Captain Azhar Ali has confirmed that his team will be without their vice-captain and wicketkeeper Sarfraz Ahmed.
Sarfraz had gone back to Pakistan to be with his mother, who is in intensive care in hospital. He will be unavailable for this month's entire five-match series.
Fast bowler Mohammad Irfan also left the team following the death of his mother.
Pakistan have retained half the players who were involved in 3-0 Test series wipeout to Australia for the ODI part of their tour.
Australia can extend their lead in the ODI rankings if they can pull off a series whitewash.
Australia lead Pakistan 33-16 head-to-head in Australia, including 15 wins in 19 ODIs this decade. – Samaa/AFP