A Soyuz capsule carrying Kelly, Kornienko and Sergey Volkov, another Russian cosmonaut, made a parachute landing on the steppe near the Kazakh city of Zhezkazgan at 10:26 a.m. (2326 GMT), about 3-1/2 hours after departing the station.
Kelly and Kornienko have been aboard the space station for 340 days, about twice as long as previous crews. Their flight sets a record for the space station and for the longest US space mission.
Volkov, who has been in space for 5-1/2 months, was the first to emerge from the capsule, to be greeted by his father Alexander Volkov, also a cosmonaut.
Kelly, extracted next, waved his hand energetically and smiled before beginning a satellite telephone conversation.
In their nearly year-long stay in space, Kelly, 52, and Kornienko, 55, have been the subjects of dozens of medical experiments and science studies trying to learn more about how the human body adjusts to weightlessness and the high-radiation environment of space.
The research aims to help the US space agency and its partners develop plans for eventual human missions to Mars that will last at least two years.
Kelly and his identical twin brother Mark, a former NASA astronaut, are also participating in genetic studies, the first to assess if genetic changes occur during long spaceflights.
Kelly’s 340-day mission eclipses the previous US record-long spaceflight of 215 days, set by former astronaut Michael Lopez-Alegria aboard the space station in 2007.
The world’s longest missions were carried out by four Soviet-era cosmonauts aboard the now-defunct Mir space station, including a flight from January 1994 to March 1995, spanning nearly 438 days by record holder Valeri Polyakov, a physician.
The International Space Station, a joint project of the United States, Russia, Europe, Japanand Canada, followed Mir and has been permanently staffed by rotating crews since 2000.
About the size of a five-bedroom house, the $100-billion station flies about 250 miles (400 km) above Earth.