Khalid Latif made his first-class debut five days shy of his 15th birthday, he wasn't really able to make an impression until after his Youth Test debut in 2003. Appointed captain of Pakistan Under-19s for the series against Sri Lanka, the right-hand opener scored 77 in the first match.
He followed that up with perhaps his greatest achievement to date - captaining Pakistan U-19s to a World Cup win in 2004. The following season saw Latif score his maiden first-class century and he finished with almost 400 runs. Consistent performances with the bat followed and Latif, after scoring close to 600 runs in the 2007-08 Quaid-e-Azam Trophy, was included in the Patron's XI line-up to play the touring Zimbabweans. With Pakistan searching for opening options, Latif duly made his ODI debut, albeit an unimpressive one, against Zimbabwe in Faisalabad.
He was dropped after the ICC World Twenty20 in 2010 but recalled a couple years later to the Twenty20 squad for the tour of Sri Lanka. He was in good form in the domestic one-day tournament prior to that, topping the run charts for Karachi Dolphins.